benötigt. Die Reaktionsgleichung dieser Reaktion sieht aus wie folgt: Arginin + 2O2 + 1,5 NADPH → Citrullin + 2 H2O + 1,5 NADP + NO. 1 Das Enzym Stickstoffmonoxid-Synthase, kurz NO-Synthase, katalysiert die Bildung von Stickstoffmonoxid aus der Aminosäure L-Arginin. Es kommt in den meisten Eukaryoten, aber auch in manchen Bakterien vor. 2 Das Enzym NO-Synthase, kurz NOS, katalysiert die Bildung von Stickstoffmonoxid NO aus L-Arginin. Bei dieser Reaktion wird L-Citrullin abgespalten. 3 Das Enzym Stickstoffmonoxid-Synthase, kurz NO-Synthase (NOS), katalysiert die Bildung von Stickstoffmonoxid (NO) aus der Aminosäure L-Arginin. 4 Nitric oxide synthases (EC ) (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO is an important cellular signaling molecule. It helps modulate vascular tone, insulin secretion, airway tone, and peristalsis, and is involved in angiogenesis and neural development. 5 Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from l-arginine, and the NO is an important cellular signaling molecule that modulates vascular tone, with insulin secretion as one of its multiple functions. From: Progress in Molecular Biology and Translational Science, 6 Nitric oxide (NO) synthases (NOSs) catalyze the formation of NO from l-arginine. We have shown previously that the NOS enzyme catalytic cycle involves a large number of reactions but can be characterized by a global model with three main rate-limiting steps. 7 Nitric oxide (NO) is synthesised from l-arginine by the enzyme NO synthase (NOS). The complex reaction involves the transfer of electrons from NADPH, via the flavins FAD and FMN in the carboxy-terminal reductase domain, to the haem in the amino-terminal oxygenase domain, where the substrate l-arginine is oxidised to l-citrulline and NO. The. 8 NO synthase: structures and mechanisms Production of NO from arginine and molecular oxygen is a complex chemical reaction unique to biology. Our understanding of the chemical and regulation mechanisms of the NO synthases has developed over the past two decades, uncovering some extraordinary features. This article reviews recent progress . 9 Bei den NO-Synthasen handelt es sich um mischfunktionelle Oxidasen, die die Reaktion der proteinogenen Aminosäure Arginin zur nicht-proteinogenen Aminosäure Citrullin und NO katalysieren. Dabei wird die Guanidino-Gruppe des Arginin zur Carboxyamid-Gruppe umgewandelt. no-synthase calcium 10 Bei der von eNOS katalysierten Reaktion wird die Guanidin-Gruppe der Aminosäure L-Arginin in Gegenwart von Sauerstoff oxidiert. Dabei entstehen die beiden. 11 no-synthase endothel 12